FIGURE

FIGURE 7

ID

ZDB-FIG-230307-16

Publication

Ma et al., 2023 - Deficiency in the cell-adhesion molecule dscaml1 impairs hypothalamic CRH neuron development and perturbs normal neuroendocrine stress axis function

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FIGURE 7

Cortisol levels and response to exogenous glucocorticoids. (A–B) Cortisol profile for 5 dpf larvae. For each sample (dot), cortisol was extracted from a pool of 30 animals. n = 6 for all groups. Median, interquartile range, and corrected p values are shown. (A) Baseline cortisol in control (black) and dscaml1−/− (red) animals. (B) Baseline-normalized cortisol fold change in control (black) and dscaml1−/− (red) animals. (C) Quantification of crhb signal intensity per cell in CRH^NPO neurons. Vehicle: n = 10 (WT), 11 (dscaml1−/−). Dex: n = 7 (WT), 11 (dscaml1−/−). Mean, standard error, and corrected p values are shown.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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