FIGURE

Figure 4

ID

ZDB-FIG-221118-103

Publication

Seo et al., 2022 - Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS

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Figure 4

Tamalin KO causes the hypomyelination of axons in the zebrafish spinal cord. Transmission electron microscopy (TEM) images reveal transverse sections through the spinal cord of wildtype or tamalin KO zebrafish at 10 dpf (a,e), 1 mpf (b,f), 2 mpf (c,g), and 4 mpf (d,h). Black arrows indicate unmyelinated axons (g), and asterisks indicate disorganized watery axons (h). (i–l) The g-ratio of myelinated axons in the spinal cord of wildtype and tamalin KO zebrafish. Unpaired t test was used to compare means from each animal. Each g-ratio has been obtained from 100 myelinated axons in eight sections of four zebrafish each (i: p = 0.0696, j–l: p < 0.0001). Scale bars: (a,e): 1 μm, (b–h): 2 μm. KO, knockout; dpf, days post fertilization; and mpf; months post fertilization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tamalin^km12/+ (AB)
Observed In:	spinal cord axon spinal cord myelination
Stage Range:	Days 7-13 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.