FIGURE

Figure 3

ID

ZDB-FIG-221018-39

Publication

Bailon-Zambrano et al., 2022 - Variable paralog expression underlies phenotype variation

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Figure 3

Zebrafish mef2 paralogs encode highly conserved MADS box (MCM1, agamous, deficiens, and SRF) and MEF2 domains.

(A) Neighbor joining tree generated by Clustal Omega Multiple Sequence Alignment tool depicts the evolutionary relationships between the different zebrafish mef2 paralogs. The distance values (branch length) are indicated, which represent the evolutionary distance between the individual amino acid sequences and a consensus sequence. (B) mef2-encoded protein sequence alignment reveals high conservation of MADS box (green) and MEF2 (yellow) domains among all six paralogs. These domains are responsible for DNA binding, dimerization, and cofactor interactions. Transcript IDs used for alignment using the HHalign algorithm are listed in the Materials and methods.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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