FIGURE

Figure 3

ID

ZDB-FIG-220921-74

Publication

Khrystoforova et al., 2022 - Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation

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Figure 3

Craniofacial deformities of adult lrp5 mutant. (A) Adult lrp5^-/- display major deformities of neuro- and viscera- craniums. (B) Schematic representation of morphometrical parameters measured na- nasofacial angle, pd- parasphenoid distance between its edges. (C, D) Nasofacial angle at 3mpf and 6mpf is significantly bigger in lrp5^-/- compared to lrp5^+/+, meanwhile parasphenoid distance is significantly shorter in lrp5^-/- adult fish at 3 and 6mpf (E, F). (G) Parasphenoid bones of lrp5^-/- are severely deformed and display a similar fracture pattern, outlined in yellow. (H) 40% of lrp5^-/- fish displayed malformed parasphenoid at 3mpf and 38.4% at 6mpf within lrp5^-/- group. At 3mpf and 6mpf lrp5^+/+ display no indication of parasphenoid deformities.(Scale bar 500µm, 3mpf n =13-15 fish, 6mpf n =12-13 fish, t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp5^{biu102/biu102} (AB)
Observed In:	mouth nasal bone parasphenoid
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)