FIGURE

Fig. 2

ID

ZDB-FIG-220912-113

Publication

Wang et al., 2022 - Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure

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Fig. 2

Ischemic injury augments TNKS1 and TNKS2 in the border area in rat hearts. (A,B) Representative immunoblots of TNKS1 and TNKS2 in the remote and border areas in MI rat hearts and sham-operated controls at 1 week (A) and 4 weeks (B) post-MI. (A) Sham: n = 8; MI Border: TNKS1, n = 7; TNKS2, n = 8; MI Remote: n = 8. (B) Sham: n = 8; MI Border: n = 7; MI Remote: n = 8. (C,D) Representative immunoblots of AXIN1 and Act-β-CAT in the remote and border areas in MI rat hearts and sham-operated controls at 1 week (C) and 4 weeks (D) post-MI. (C) Sham: n = 8; MI Border: n = 8; MI Remote: n = 8. (D) Sham: n = 8; MI Border: AXIN1, n = 8; Act-β-CAT, n = 7; MI Remote, n = 8. (E,F) Representative immunoblots of DICER and ΔDICER in the remote and border areas in MI rat hearts and sham-operated controls at 1 week (E) and 4 weeks (F) post-MI. (E,F): Sham, n = 8; MI Border, n = 8; MI Remote, n = 8. The graphs represent quantifications of three replicate blots for the indicated proteins relative to GAPDH. The results are presented as fold change compared to controls. The blurry or oversaturated bands were excluded from the quantification. Data are presented as mean ± SD. One-way ANOVA with Tukey adjustment for multiple comparisons: * p < 0.05, ** p < 0.01, *** p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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