FIGURE

Fig. 4

ID

ZDB-FIG-220803-26

Publication

Wolińska-Nizioł et al., 2022 - Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide

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Fig. 4

Deficiency of Tollip does not worsen the phenotypic hallmarks of Gaucher disease in the zebrafish model. (A) The general phenotype of zebrafish adults (3 mpf) of the examined mutant genotypes (tollip ^+/+/gba1 ^−/−; tollip ^−/−/gba1 ^+/+; tollip ^−/−/gba1 ^−/−), compared to the wild‐type genotype (tollip ^+/+/gba1 ^+/+). Scale bar 1 cm. (B) Swimming velocity examined in the mutant and wild‐type lines. Data are averaged within the tested groups, triangles indicate individual fish (n = 8 for the tollip ^+/+/gba1 ^+/+, tollip ^+/+/gba1 ^−/−, tollip ^−/−/gba1^+/+/ groups, n = 10 for the tollip ^−/−/gba1 ^−/− group) and the error bars represent SEM. t‐test, ns.—nonsignificant, **P < 0.005, ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gba1^sh391/sh391 (AB/TL) tollip^{waw401/waw401} (AB/TL) gba1^sh391/sh391; tollip^{waw401/waw401} (AB/TL)
Observed In:	whole organism whole organism swimming behavior
Stage:	Adult

Phenotype Detail

Acknowledgments

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