FIGURE

Figure 1

ID

ZDB-FIG-220801-15

Publication

Gessler et al., 2022 - Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling

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Figure 1

The involvement of adenosine receptors in zebrafish pronephros repair. (A) In situ hybridization revealed upregulation of zebrafish adora1a and adora1b after a laser-induced injury. Images were obtained two hours after the injury. (B) Depletion of zebrafish adora1a or adora1b by splice- (SBM) or translation- (TBM) blocking morpholino oligonucleotides (MO) delayed the repair process. (C) In situ hybridization revealed upregulation of zebrafish adora2aa and adora2ab after a laser-induced injury. Images were obtained two hours after the injury. (D) Depletion of zebrafish adora2aa or adora2ab by SBM delayed the repair process (mean ± SEM; 2-way ANOVA).

Expression Data

Genes:	adora1a adora1b adora2aa adora2ab
Fish:	WT
Condition:	ablation: pronephros
Anatomical Term:	pronephros
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT WT + MO1-adora1a WT + MO1-adora1b WT + MO2-adora2aa WT + MO2-adora2ab
Condition:	ablation: pronephros
Knockdown Reagents:	MO1-adora1a MO1-adora1b MO2-adora2aa MO2-adora2ab
Observed In:	pronephros pronephros regeneration
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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