FIGURE

Figure 2

ID

ZDB-FIG-220801-136

Publication

Hawkey-Noble et al., 2022 - Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis

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Figure 2

Calcein staining illustrating the impact of foxl1 loss on craniofacial development and calcification. (A) Embryos of WT aged 6 and 10 dpf (n = 173 and 99, respectively) as well as those of foxl1^-/- (n = 116 and 65, respectively). WT embryos at both 6 and 10 dpf exhibit normal craniofacial development and calcification of all jaw structures. foxl1^-/- embryos show a delayed calcification in the ceratohyal and hyomandibula (red boxes) at 6 dpf yet appear mostly recovered by 10 dpf. (B) The proportion of embryos with delayed calcification in foxl1 mutants is statistically significant (Fisher’s *** p = 0.0001) when compared to wildtype siblings. PQ, palatoquadrate; M, Meckel; HY, hyomandibula (hyosympletic); BH, basihyal; OP, opercula; CH, ceratohyal. Scale bars are 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxl1^nfl1/nfl1 (AB)
Observed In:	ceratohyal cartilage ossification hyomandibula ossification
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

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