FIGURE

Figure 2.

ID

ZDB-FIG-220717-48

Publication

Bresciani et al., 2021 - Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

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Figure 2.

Development of cd41:GFP⁺ hematopoietic precursors in runx1^del8/del8 AGM and CHT. (A) Snapshots of the AGM region of runx1^del8/del8 and control sibling Tg(cd41:GFP); Tg(kdrl:mCherry) at 52 hours postfertilization (hpf), obtained from time-lapse recordings on a confocal microscope (supplemental Movies 1 and 2). cd41:GFP⁺ mCherry⁺ double-positive cells are indicated with white asterisks. (B-C) Live confocal imaging of the CHT (B) and AGM (C) regions in the Tg(cd41:GFP); (B) Tg(kdrl:mCherry) embryos at 3 dpf. cd41:GFP⁺ cells are found in the CHT. (C) Residual cd41:GFP⁺ cells (white asterisks) are still detectable in the AGM of runx1^del8/del8.

Expression Data

Genes:	DsRed EGFP
Fish:	runx1^hg96/+; la2Tg/la2Tg; sd2Tg/sd2Tg runx1^hg96/hg96; la2Tg/la2Tg; sd2Tg/sd2Tg
Anatomical Terms:	caudal hematopoietic tissue hematopoietic multipotent progenitor cell caudal hematopoietic tissue vasculature ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ventral wall of dorsal aorta vasculature
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	runx1^hg96/hg96; la2Tg/la2Tg; sd2Tg/sd2Tg
Observed In:	ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ventral wall of dorsal aorta regulation of hematopoietic stem cell migration
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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