FIGURE

Fig. 2

ID

ZDB-FIG-220527-19

Publication

Xiao et al., 2022 - Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231

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Fig. 2

RNA-sequencing of MDA-MB-231 parental, F1, and F2 populations reveals increased expression of EMT genes and metastasis-associated genes in F1/F2 compared to parental cell populations. a Principal-component analysis reveals transcriptomic differences between all three subpopulations. b A heatmap depicting RNA-sequencing expression of a select panel of epithelial and mesenchymal markers is shown. c A clustergram of the overall transcriptomic landscape of the parental, F1, and F2 populations. d A volcano plot depicting the most significantly upregulated and downregulated genes when comparing the F1 and F2 populations relative to the common parental control. e A KEGG analysis was performed, revealing enrichment of several important cancer-associated pathways in the F1 and F2 populations. f GSEA analysis identified enrichment of the hallmarks gene set Epithelial-Mesenchymal Transition and TNFα Signaling via NF-kβ, among other gene sets

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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