FIGURE
Figure 1
- ID
- ZDB-FIG-220324-23
- Publication
- Yan et al., 2022 - Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption
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Figure 1
High-cholesterol diet-induced vascular defects and decreased ETFA expression in zebrafish larvae. Tg Flk1: EGFP zebrafish larvae were fed with different concentrations of high-cholesterol-containing diet (HCD) from 5 days postfertilization (dpf) to 15 dpf, followed by various evaluations. (a, b) HCD induced shorten body length of zebrafish embryos. (a) Representative phage-contrast images of 15dpf larvae fed with different concentrations of HCD (0%, 4%, 6%, 8%, and 10%), scale ; (b) statistical analysis of the total body length (mm) of the zebrafish larvae (one-way ANNOVA, , ); (c–e) HCD-induced developmental vascular defects in zebrafish larvae. (c) Representative image of vessel morphologies in caudal fins of 15dpf Tg Flk1: EGFP zebrafish larvae. Green EGFP signals represent VEGR2+ vessels, scale . (d) Statistical analysis of vessel length (μm) in caudal fins of HCD-fed zebrafish larvae (one-way ANNOVA, , ); (e) statistical analysis of the vessel number in caudal fins of HCD-fed zebrafish larvae (one-way ANNOVA, , , ); (f) RT-qPCR analysis of ETFA gene expression in HCD-fed zebrafish larvae. (one-way ANNOVA, ); (g) RT-qPCR analysis of HIF1 gene expression in HCD-fed zebrafish larvae. (one-way ANNOVA, ).
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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