FIGURE

Figure 2

ID

ZDB-FIG-220303-9

Publication

Benardais et al., 2022 - p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions

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Figure 2

Characterization of pS6RP expression in oligodendroglial cells. (A–C) Co-immunolabelling for pS6RP and Sox10 (A), pS6RP and PDGFRα (B), pS6RP and CC1 (C) in the dorsal funiculus of PND7 WT mice. Double-positive cells are indicated by arrows. (D) Number of pS6RP⁺PDGRα⁺ OPCs/mm² from PND0 to PND10. (E) The number of CC1⁺ differentiated oligodendrocytes expressing pS6RP from PND0 to PND21. Note that pS6RP is transiently expressed in CC1⁺ differentiated oligodendrocytes. (F) Although transient, pS6RP is predominantly located in CC1⁺ differentiated oligodendrocytes between PND4 and PND10. Data represent mean ± SEM; N = 3 independent experiments for each developmental stage. ANOVA followed with post hoc Tukey's pairwise multiple comparison tests: *P < 0.05; **P < 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. Panels (A–C) are counterstained with DAPI. Scale bar (A–C): 20 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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