Fig. 7
Genes that are upregulated during zebrafish scale regeneration are enriched for genes involved in human musculoskeletal disease. A Schematic describing the experimental design used to show that zebrafish DEGs are enriched for genes that cause rare monogenetic skeletal disorders in humans, and for genes that are robustly associated with polygenetic human traits: bone mineral density and height. B Bar plot summarising results of enrichment analysis involving genes that that cause different monogenetic dysplasia subgroups. The size of each bar reflects the strength of evidence of enrichment [i.e. hypergeometric-log10 (p-value). Only dysplasia subgroups with nominal evidence of enrichment (p-value < 0.05) are shown. Human gene symbols corresponding to upregulated genes that have human orthologues that cause different monogenetic dysplasia subgroups in humans are listed |