FIGURE

Fig. 2.

ID

ZDB-FIG-220104-54

Publication

Habjan et al., 2021 - Anti-tuberculosis Compound Screen using a Zebrafish Infection Model identifies an Aspartyl-tRNA Synthetase Inhibitor

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2.

Screening a library of anti-mycobacterial compounds in zebrafish-infection model identifies 14 hit-compounds. (A) Schematic representation of the screen design. Compounds active against Mtb and M. marinum in vitro were tested in the zebrafish embryo-M. marinum yolk-infection model. (B) Hit compounds were tested in a dose-response assay. Each data point represents the integrated red fluorescence intensity of a single zebrafish embryo, and the signal of each group (10-20 embryos) is expressed as mean±s.e.m. Statistical significance was determined by one-way ANOVA, following Dunnett's multiple comparison test by comparing the signal from the DMSO-treated control sample with each treatment group (*P≤0.05, **P≤0.01, ***P≤0.001, ****P≤0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.