Fig 7
- ID
- ZDB-FIG-211201-21
- Publication
- Guan et al., 2021 - Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox
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RIC works through activation of nrf2a in zebrafish.
(A) Kaplan-Meier survival curve of zebrafish subjected to LPS treatment. nrf2a knockdown resulted in earlier mortality in response to LPS exposure (80 μg/mL) and the protective effect of RIC Plasma was abolished in nrf2a knockdown zebrafish (n = 26–33). (B) RIC Plasma from Nrf2 KO mice did not exert survival benefit in response to LPS exposure (80 μg/mL) induced mortality in zebrafish (n = 26–30). (C) Real time PCR showed the expression level of duox in the fish treated with the plasma in nrf2a-knockdown fish. *p<0.05. (D) Real time PCR showed the expression level of hmox1a in the fish treated with the plasma in nrf2a-knockdown fish. *p<0.05. |