Figure 4

Figure 4. Interpretative scheme showing localization of scpp5 transcripts and Zns-5 detection during zebrafish tooth development. Panel (A) shows a representation of scpp5 expression during first and second generation and adult tooth formation, from the stage of initiation and morphogenesis to tooth attachment, and of Zns-5 detection in adult teeth, at the same developmental stages. Panel (B) shows the comparison between the expression of scpp5 and the localization of Zns-5, the former being exclusively expressed by ameloblasts and odontoblasts and the latter by cells forming the pedicel and by osteoblasts. In both panels, the adult tooth is depicted in a similar way as the first/second-generation teeth, although the tooth is larger, with thicker walls, and is attached to bone with all cartilage having been resorbed in this area. cb, ceratobranchial cartilage; cl, cervical loop; and dp, dental pulp.