FIGURE

Figure 5

ID

ZDB-FIG-210902-82

Publication

Lu et al., 2021 - Lipopolysaccharides Enhance Epithelial Hyperplasia and Tubular Adenoma in Intestine-Specific Expression of kras^V¹² in Transgenic Zebrafish

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Figure 5

Expression of kras^V¹² with LPS treatment enhanced the increase in p-AKT in intestinal epithelial cells. (A,C) Immunofluorescence staining (red) was performed on intestinal paraffin sections of WT (N = 20), WT/LPS (N = 20), kras+ (N = 20), and kras+/LPS (N = 20) zebrafish. (B,D) Immunofluorescence staining of p-AKT and p-ERK as a marker of RAS signaling and quantification of the number of positive cells. Differences among the variables were assessed using Student’s t-tests. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bar: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT gz37Tg
Conditions:	chemical treatment by environment: lipopolysaccharide chemical treatment by environment: mifepristone
Observed In:	intestinal epithelial cell MAPK cascade intestinal epithelial cell phosphatidylinositol 3-kinase/protein kinase B signal transduction
Stage:	Adult

Phenotype Detail

Acknowledgments

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