FIGURE

Figure 7

ID

ZDB-FIG-210808-12

Publication

Dahlén et al., 2021 - THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior

Other Figures

All Figure Page

Back to All Figure Page

Figure 7

Potential mechanisms underlying the associations between Cannabis consumption and risks of psychosis/schizophrenia-like symptoms, with the current study’s pharmacological approaches. Δ9-tetrahydrocannabinol (THC) reduces N-methyl-D-aspartate (NMDA) release via NMDA receptor antagonism. THC also inhibits γ‐aminobutyric acid (GABA) release from interneurons in the prefrontal cortex, potentiating dopamine release. Both NMDA receptor hypoactivity and heightened dopaminergic signaling are hallmarks of schizophrenia. Pentylenetetrazol (PTZ).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.