FIGURE

Figure 5

ID

ZDB-FIG-210711-10

Publication

Wang et al., 2021 - BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration

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Figure 5

Inhibition of BMP and Notch signaling pathways differentially suppresses FUCCI expression. (A) Time-lapse images of Tg(vmhc:mCherry-NTR; myl7:mAG-zGeminin) hearts showed differential patterns of zGem+ CMs in ablated, DAPT-treated ablated and DM-treated ablated groups at 0-72 hpt. Scale bars, 50 µm. hpt, hours post MTZ-treatment; CM, cardiomyocyte; DM, dorsomorphin. (B, C) Quantification of zGem+ CM numbers in the whole heart (B) or in the atrium only (C) of ablated and DAPT-treated ablated groups at 24, 48 and 72 hpt. Mean + SD, N=8-15 for each group, Student's t-test, *, P <0.05, ***, P < 0.001, ****, P < 0.0001. (D, E) Quantification of zGem+ CM numbers in the whole heart (D) or in the atrium only (E) of ablated and DM-treated ablated groups at 24, 48 and 72 hpt. Mean + SD, N=6-13 for each group, Student's t-test, *, P <0.05, **, P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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