FIGURE
Fig. 7
Fig. 7
Smooth muscle within the OFT is absent in RA-deficient embryos. (A–D) IHC of Elnb (green) and Mhc (red) in hearts of (A,B) WT sibling and nls mutant embryos and (C,D) DMSO- and DEAB-treated embryos at 72 hpf. Number of embryos examined per condition: WT n = 6, nls n = 8, DMSO-treated n = 12, DEAB-treated n = 9. Views are lateral with arterial pole of the heart up. Arrows indicate the Elnb in WT sibling and DMSO-treated and the lack of Elnb in nls mutant and DEAB-treated at the arterial poles of the hearts. Scale bar – 50 μm. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 473, Duong, T.B., Holowiecki, A., Waxman, J.S., Retinoic acid signaling restricts the size of the first heart field within the anterior lateral plate mesoderm, 119-129, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.