FIGURE

Figure 3

ID

ZDB-FIG-210130-36

Publication

da Silva et al., 2020 - NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss

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Figure 3

Abnormal cartilage behaviour and macula hair distribution in ears of ncoa3−/− A) 3D renders from confocal images of wt and ncoa3−/− carrying Tg(col2:mcherry, notch:gfp) to show cartilage and cristae, respectively. Arrows indicate abnormal cartilage cell behaviour (cell exostosis). (ac = anterior crista, lc = lateral crista, pc = posterior crista). Scale bars = 50 μm. Regions of anterior crista and macula were zoomed in. Scale bars = 20 μm. B) Phalloidin staining and confocal imaging to show the distribution of hair cells. Yellow dashed box to show zoomed in region. Abnormal distribution of hair cells was observed in the macula (dashed cyan arrows). Scale bars = 50 μm, zoomed in region = 20 μm.

Expression Data

Genes:	EGFP mCherry
Fish:	ncoa3^{bsl456/bsl456}; hu5910Tg; um14Tg
Anatomical Terms:	chondrocyte lateral crista
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ncoa3^{bsl456/bsl456}; hu5910Tg; um14Tg
Observed In:	auditory receptor cell stereocilium organization lateral crista chondrocyte macula hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.