FIGURE

FIGURE 5

ID

ZDB-FIG-210103-27

Publication

Wu et al., 2020 - Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling

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FIGURE 5

Validate the microarray data with qPCR for the five genes upregulated by OF (A‐G), and three genes downregulated by OF (H–J) in [HBx,src] and [HBx,src,p53^−/+] transgenic zebrafish. The OF upregulated and downregulated genes from microarray and survival probability in liver cancer patients according to The Cancer Genome Atlas (TCGA) database. A‐G, Genes were upregulated by oligo‐fucoidan correlated to prolong survival rate in HCC patients. H‐J, Genes were downregulated by oligo‐fucoidan, and their expression correlated to poorer survival rate in HCC patients. Statistical significance was calculated by t‐test: *P ≤ .05, **P ≤ .01, ***P ≤ .001.

Expression Data

Genes:	arl5c cpb1 foxo3b gadd45ba gtf3c5 hnf4a mxd3 pck1 rorab slc19a2
Fish:	nn1002Tg; nn1003Tg tp53^zdf1/+; nn1002Tg; nn1003Tg
Conditions:	increased food availability chemical treatment by gavage: fucoidan, increased food availability
Anatomical Term:	whole organism
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nn1002Tg; nn1003Tg tp53^zdf1/+; nn1002Tg; nn1003Tg
Condition:	chemical treatment by gavage: fucoidan, increased food availability
Observed In:	whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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