FIGURE

Fig. 3.

ID

ZDB-FIG-200910-20

Publication

Oppel et al., 2020 - suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3.

Observation of multiple tumor foci in p53/nf1/suz12-deficient zebrafish lines. (A) Fluorescence microscopy image of an adult p53^+/−, nf1b^−/−, nf1a^+/⁻, suz12a^+/⁻, suz12b^+/⁻ fish bearing two independent GFP-positive tumors in abdominal and anal locations. (B) Proportion of fish with multiple lesions in different suz12-mutant populations with additional p53^+/−, nf1b^−/−, nf1a^+/⁻ or p53^+/−, nf1b^−/−, nf1a^+/+ backgrounds. Data are mean±s.d. of populations with any combination of three out of four (suz12^{+/−/−/−}), two out of four (suz12^+/+/−/−), or one out of four (suz12^+/+/+/−) suz12 alleles knocked out. The total number of fish analyzed is indicated (n). P-values were calculated using Student's t-tests. (C) Representative HE-stained sections of p53/nf1/suz12-deficient fish with two separate tumor foci. Squares indicate areas shown in magnified images below.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.