FIGURE

Fig. 2

ID

ZDB-FIG-200813-4

Publication

Lex et al., 2020 - Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish

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Fig. 2

tert−/− tissues increase melanoma invasiveness and progression. (A) Hematoxylin and eosin (H and E) images of melanoma arising in a WT (Upper) or tert−/− recipient fish. Strong infiltration into other tissues was typical in tert−/− fish but not in WT (arrowheads). (B) Melanomas were staged according to histopathology into benign lesions (melanosis), noninvasive and invasive malignant tumors (P = 0.0269; WT n = 9; tert−/− n = 10). (C) Analysis of malignant tumors for cellular atypia (P = 0.0278; WT n = 5; tert−/− n = 7). (D) Representative immunofluorescence images of PCNA-positive cells (red) in melanoma (green) developed in WT chimeras and in tert−/− chimeras. Dashed lines locate the skin (no green fluorescence), squares show the place of amplification, and arrows indicate PCNA-positive cells. (E) Quantification of PCNA-positive melanoma cells in WT and tert−/− chimeras. Data are represented as mean ± SEM. *P < 0.05; n = 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; tert^{hu3430/hu3430}; mpv17^a9/a9
Observed In:	whole organism melanocytic tumor
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA