FIGURE

Fig. 4

ID

ZDB-FIG-200521-14

Publication

Caetano-Lopes et al., 2020 - Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish

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Fig. 4

csf1r genes show combinatorial effects in regulating patterning of the dentition and tooth number.

(A-D,F) Alizarin Red stained pharyngeal arches from 4 month post-fertilization (mpf) csf1r mutants and wild-type siblings. Numbers on the bottom represent the range of tooth numbers on each arch (n=7). Arrows indicate buildup of bone surrounding base of teeth in csf1ra and csf1rb mutants (B,C). (E) Quantification of the number of teeth represented in csf1r mutants, double mutants and wild-type siblings (****P<0.0001). (F) Higher magnification images of dentitions from csf1ra;csf1rb double mutants showing organization of supernumerary teeth into distinct tracts (yellow line) associated with a row of normal tooth germ patterning in wild-type dentitions (Fig. S6). (G-J) Localization of ctsk-positive cells (magenta) on the dentary of zebrafish csf1r mutants. Bottom, overlay with calcein stain (cyan).

Expression Data

Gene:	DsRed
Fish:	mh201Tg (AB) csf1ra^mh5/mh5; mh201Tg (AB) csf1rb^mh108/mh108; mh201Tg (AB) csf1rb^mh112/mh112; csf1ra^mh5/mh5; mh201Tg (AB)
Anatomical Term:	ceratobranchial 5 tooth osteoclast
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	csf1ra^mh5/mh5 (AB) csf1rb^mh108/mh108 (AB) csf1rb^mh112/mh112; csf1ra^mh5/mh5 (AB)
Observed In:	ceratobranchial 5 bone ceratobranchial 5 bone odontogenesis ceratobranchial 5 tooth ceratobranchial 5 tooth basal surface
Stage:	Adult

Phenotype Detail

Acknowledgments

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