Fig. s5
- ID
- ZDB-FIG-200518-9
- Publication
- McClean et al., 2020 - Early cell-autonomous accumulation of neutral lipids during infection promotes mycobacterial growth
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a. Comparison of infection burden at 12 hpi, 3 dpi, and 6 dpi in animals infected with wild-type, yrbe4aTn22523, or yrbe4bTn5819 and then treated with vehicle alone (DMSO) or 1 μM ezetimibe. Infection burdens at the initial timepoint showed no difference in burden at 12 hpi between wild-type, yrbe4aTn22523, or yrbe4bTn5819. By 3 dpi a burden difference was observed between wildtype and yrbe4aTn22523 (p<0.0001) but not between wildtype and yrbe4bTn5819. By 6dpi differences were observed between wildtype and both yrbe4aTn22523 and yrbe4bTn5819 (p<0.0001) all in untreated strains. Reduced burden is observed between ezetimibe-treated and untreated wildtype samples (p = 0.003). |