FIGURE

Fig. 8

ID

ZDB-FIG-200413-48

Publication

Chestnut et al., 2019 - Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells

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Fig. 8

A comparison of vascular development in heterozygous etv2 ci32Gt+/−; UAS:GFP and homozygous etv2 ci32Gt−/−; UAS:GFP embryos. GFP expression is apparent in vascular progenitors of the trunk axial vasculature (arrow, A) in etv2 ci32Gt+/−; UAS:GFP embryos. This domain is broader and disorganized in etv2 ci32Gt−/−; UAS:GFP embryos, E. Vascular progenitors fail to coalesce into vascular cords in etv2 ci32Gt−/−; UAS:GFP embryos at 25 hpf (arrows, F, compare with C). Intersegmental vessels (ISVs) are absent in etv2 ci32Gt−/−; UAS:GFP embryos between 25 and 48 hpf, F and G. Some ISV sprouts are apparent at 72 hpf but are shorter and mispatterned (H, arrows)

Expression Data

Gene:	EGFP
Fish:	etsrp^ci32Gt/+; nkuasgfp1aTg etsrp^{ci32Gt/ci32Gt}; nkuasgfp1aTg
Anatomical Terms:	anterior lateral plate mesoderm axial vasculature blood vessel endothelium caudal vein plexus common cardinal vein cranial vasculature dorsal aorta embryonic blood vessel endothelial progenitor cell intersegmental vessel posterior cardinal vein primordial vasculature vascular endothelium
Stage Range:	14-19 somites to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	etsrp^{ci32Gt/ci32Gt}; nkuasgfp1aTg
Observed In:	blood vessel development common cardinal vein cranial vasculature intersegmental vessel
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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