FIGURE

Fig. 4

ID

ZDB-FIG-200327-2

Publication

Tiraboschi et al., 2020 - New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome

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Fig. 4

Dendritic arborization in scn1labmut/mut larvae. A, scn1labmut/mut larvae show a reduced number of dendritic arbors at 3 days postfertilization (dpf). Significance of differences was calculated using an unpaired, two‐tailed t test. * P < .05. B, Representative images of dendritic arbors in the neuropil of wild‐type (WT) and scn1labmut/mut larvae at 3 dpf. Scale bars = 25 μm. C, Reduction in dendritic arborization in scn1labmut/mut larvae observed at 6 dpf can be rescued by the addition of 50 μmol/L of fenfluramine (FEN), but not 10 μmol/L of diazepam (DZP), from 3 dpf until 6 dpf. Significance of differences was calculated using one‐way analysis of variance with Sidak post hoc test. * P < .05, *** P < .001. D, Representative images of dendritic arbors in the neuropil of WT and scn1labmut/mut larvae at 6 dpf, with or without prior incubation in 50 μmol/L of FEN or 10 μM of DZP from 3 dpf onward. Scale bars = 25 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scn1lab^{uio202/uio202} (AB)
Conditions:	chemical treatment: diazepam chemical treatment: fenfluramine
Observed In:	optic tectum GABAergic neuron
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

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