FIGURE

Figure 2.

ID

ZDB-FIG-200302-22

Publication

Son et al., 2020 - Dopaminergic Co-Regulation of Locomotor Development and Motor Neuron Synaptogenesis is Uncoupled by Hypoxia in Zebrafish

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Figure 2.

Hypoxia causes impaired motor behavior in larval and adult animals. A, Experimental set-up for hypoxia (a) and time line (b) of hypoxia exposure and analysis. B, Schematic of behavioral testing paradigm. C, Data plots show impaired motor behavior in hypoxia-exposed larvae, each point is a separate animal. Mean shown, ANOVA, ****p < 0.0001, ***p < 0.001. D, top, Heat-map of adult zebrafish (six-month-old) exposed to hypoxia (3- to 4-dpf 5% pO₂) shows decreased swimming. Below, Hypoxia-exposed zebrafish have persistent decreases in velocity and distance swum as adults animals (normoxia n = 8, pre-hypoxia n = 10); *p < 0.05; SD shown).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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