FIGURE

Figure 9.

ID

ZDB-FIG-200210-47

Publication

Nagashima et al., 2019 - Midkine-a is required for cell cycle progression of Müller glia glia during neuronal regeneration in the vertebrate retina

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Figure 9.

Activation of the ALK receptor is required for Müller glial to proliferate. A, Double immunostaining for PCNA (magenta) and pAlk (green). PCNA⁺ cells express pAlk in WT retina at 2 dpl, whereas pAlk immunostaining was not detected in mdka^mi5001 retina. Scale bar, 30 μm. B, Pharmacological inhibition of Alk using TAE684 suppresses proliferation in the WT retinas after a lesion. C, Counts of PCNA⁺ proliferative cells in DMSO- or TAE684-treated WT retinas at 3 dpl. n = 7. *p = 0.0011 (nonparametric Mann-Whitney-Wilcoxon).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, light damage: eye photoreceptor cell
Observed In:	regenerating tissue cell population proliferation retina cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurosci.