FIGURE

Figure 4

ID

ZDB-FIG-200125-15

Publication

Chen et al., 2020 - Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model

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Figure 4

Effects of berberine (BBR) on the hepatic oxidative stress in high-cholesterol diet (HCD)-induced zebrafish larvae. (A) Liver volume rendering of reactive oxygen species (ROS) staining showed that BBR (5 μM) attenuated hepatic ROS level in HCD-induced Tg (fabp10a: dsRed) zebrafish. ROS generation in the Tg (fabp10a: dsRed) zebrafish liver treated with HCD. Hepatic ROS were detected with CellROX^® Green Reagent. Bar = 100 μm. (B) Quantitative analysis of ROS throughout the entire zebrafish liver. Effects of BBR (5 μM) on the glutathione (GSH) (C) and malondialdehyde (MDA) (D) levels in HCD-induced zebrafish larvae. ^#Compared with the HCD group, P < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz15aTg
Conditions:	high cholesterol chemical treatment by environment: berberine, high cholesterol
Observed In:	liver glutathione liver malonaldehyde liver reactive oxygen species
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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