FIGURE

Fig. 5

ID

ZDB-FIG-200124-58

Publication

Batalha et al., 2019 - Polymeric nanobiotics as a novel treatment for mycobacterial infections

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Fig. 5

In vivo testing of multi-drug nanobiotics in a M. marinum-infected zebrafish larval model. a. Confocal microscopy images showing nanobiotics-induced macrophage mobilization in vivo. Suspension of coumarin 6-labelled Nano Blank (green) was injected into the muscle of 3 dpf Tg(mpeg1:mCherryCAAX)sh378 zebrafish line harbouring red macrophages. Macrophage chemotaxis towards injection site has been monitored at 1 and 4 h post injection (scale bar, 20 μm). b. Quantification and c. Confocal imaging of coumarin 6-labelled Nano Blank (green) uptake by M. marinum-infected macrophages (red) after 4 h post infection (scale bar, 1 μm). d. Confocal imaging showing the repartition and accumulation of coumarin 6-labelled Nano Blank (green) into a M. marinum (red)-granuloma (left, scale bar, 5 μm) and a mycobacterial cord structure (right, scale bar, 5 μm). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sh378Tg
Condition:	bacterial treatment by injection: Mycobacterium marinum M
Observed In:	macrophage chemotaxis
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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