FIGURE

Fig. 6

ID

ZDB-FIG-200115-42

Publication

Monestime et al., 2019 - CoRest1 regulates neurogenesis in a stage-dependent manner

Other Figures

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Fig. 6

Enhanced neurogenesis in MZrcor1 mutants. Whole mount RNA in situ hybridization of MZrcor1 and related wild‐type embryos at 13 hpf (A,B) and 24 hpf (C,D) using elavl3 probe reveals ectopic expression of elavl3 in the midbrain and tegmentum at 13 hpf and increased expression along the midline from midbrain to tail at 24 hpf (as indicated by bar). Quantification of domain expression (indicated by bar graph). The average width of the elavl3 domain in the MZrcor1 was 47.7 ± 1.5 µm compared to 36.9 ± 2 µm for the wild‐type controls. E. Dorsal views of 26 hpf (F,I), 50 hpf (G,J), and 98 hpf (H,K) of Tg(elavl3:GFP);rcor1^sbu54/sbu54 mutants show increased differentiating neurons at 24 hpf in midbrain and hindbrain. L. Quantification of fluorescence levels of Tg(elavl3:GFP);rcor1^sbu54/sbu54 larva and sibling controls quantified at 26, 50, and 98 hpf (ROI indicated by white bracket). (*P < 0.05) (Scale bar = 20 µm). hpf, hours postfertilization

Expression Data

Genes:	EGFP elavl3
Fish:	WT rcor1^sbu54/sbu54 knu3Tg rcor1^sbu54/sbu54; knu3Tg
Anatomical Terms:	head midbrain neural rod midline column neuron
Stage Range:	5-9 somites to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rcor1^sbu54/sbu54 rcor1^sbu54/sbu54; knu3Tg
Observed In:	head midbrain neural rod midline column neuron differentiation
Stage Range:	5-9 somites to Day 4

Phenotype Detail

Acknowledgments

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