FIGURE

Fig. 3

ID

ZDB-FIG-191101-18

Publication

Collery et al., 2019 - Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein

Other Figures

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Fig. 3

(A) Gross dorsal morphology of wild-type zebrafish shows streamlined eyes lying close to the contours of the head. (B) Homozygous lrp2 C23X mutant zebrafish documented by Veth et al. (2011), and others, show buphthalmic eye enlargement. (C)Occasional unilateral eye enlargement is seen in the C23X allele. (D) Heterozygous zebrafish with one lrp2 S4424N^* allele and one wild-type allele are similar to wild-type siblings and show no eye enlargement. (E)Homozygous zebrafish carrying two S4424N^* alleles leading to premature protein truncation upstream of the Lrp2 transmembrane domain show buphthalmic eye enlargement similar to C23X homozygotes. (F) Occasional unilateral eye enlargement was seen in S4424N^*/S4424N^* homozygotes, similar to C23X homozygotes. Scale bar = 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp2a^mw1/mw1 lrp2a^mw90/mw90 lrp2a^mw90/+
Observed In:	eye eye anterior-posterior axis lens retina
Stage:	Adult

Phenotype Detail

Acknowledgments

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