FIGURE

Fig. 1

ID

ZDB-FIG-190925-19

Publication

Gath et al., 2019 - Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development

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Fig. 1

mab21l2 mutants possess complex eye defects that include small lenses, microphthalmia, coloboma, and corneal malformations. A‐L,N,O: Whole‐mount images of wild‐type (A‐E,K,L) and mab21l2^−/− (F‐J,N,O) mutant embryos. Compared with wild‐type embryos, mab21l2^−/− mutants display lens defects, microphthalmia and misshapen eyes beginning at 24 hpf (compare A‐E,K,L with F‐J,N,O). Arrowheads in I, J indicate colobomas present in mab21l2^−/− mutants. M,P,Q‐U: Ventral whole‐mount images of wild‐type (G,J) and mab21l2^−/− (H,I,K) embryos at time points indicated. Note corneal malformations and lens displacement in mab21l2^−/− mutants (arrows in P,R,S,U). Scale bars = 100 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mab21l2^au10/au10 (AB)
Observed In:	closure of optic fissure eye lens optic cup optic fissure retina retinal pigmented epithelium
Stage Range:	Prim-5 to Day 5

Phenotype Detail

Acknowledgments

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