FIGURE

Fig. 3

ID

ZDB-FIG-190913-69

Publication

Toms et al., 2019 - Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy

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Fig. 3

Increased mitochondrial abundance and altered phagosome clearance in the retinal pigment epithelium (RPE) of obe^td15zebrafish. TEM cross-sections of the RPE show little difference at 3 months post fertilization (mpf) (a,b), while at 6 mpf (c,d) and 12 mpf (e,f) there is a significant increase in the number of mitochondria (M) in obe^td15 compared to wild-type (WT) eyes. Additionally, there is a significant increase in the number of phagosomes (P) in obe^td15 eyes at 3 mpf and 6 mpf. Bar charts displaying numbers of phagosomes and mitochondria per µm length of RPE are shown in (g,h). OS, photoreceptor outer segments; BM, Bruch’s membrane. Results are mean ± SEM (n = 3). **p < 0.01, ***p < 0.001. Scale bars = 2 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kcnj13^td15/td15
Observed In:	retinal pigmented epithelium mitochondrion retinal pigmented epithelium phagocytic vesicle
Stage:	Adult

Phenotype Detail

Acknowledgments

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