FIGURE

Figure 1

ID

ZDB-FIG-190723-395

Publication

Yang et al., 2019 - Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway

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Figure 1

LIG increases bone mass in vivo. (a) Calcein staining of zebrafish larvae at 9 dpf. Scale bars, 500 μm. Arrowheads, bone calcein staining. (b) Number of calcein-stained vertebrae in zebrafish at 9 dpf. Error bars indicate s.e.m., n = 13 for each group. ^###P ≤ 0.001 vs. control group. **P ≤ 0.01, ***P ≤ 0.001 vs. model group. (c) The expression mRNA for Alp, Runx2a, sp7, and BMP2b were measured by quantitative RT-PCR in zebrafish at 9 dpf. Error bars indicate s.e.m. (n = 4). ^#P ≤ 0.05, ^###P ≤ 0.001 vs. control group. *P ≤ 0.05, **P ≤ 0.01 vs. model group.

Expression Data

Genes:	alpl bmp2b runx2a sp7
Fish:	WT
Conditions:	chemical treatment by environment: prednisolone chemical treatment by environment: (Z)-ligustilide
Anatomical Term:	whole organism
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: prednisolone chemical treatment by environment: (Z)-ligustilide
Observed In:	skeletal tissue skeletal tissue bone mineralization whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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