FIGURE

Fig. 2

ID

ZDB-FIG-190723-1401

Publication

Pei et al., 2019 - AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair

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Fig. 2

Loss of Apex1 protein in WT embryos alters brain morphology.

a Brain abnormalities at 24 hpf after Apex1 knockdown. Embryos microinjected with Apex1 MO (KD) had enlarged forebrains, indicated with arrows. Darkfield imaging (middle panels) highlights forebrain abnormality (arrow) in KD compared with control embryos. Dorsal views of KD embryos (third panel) show abnormality of the brain ventricle in knockdown embryos relative to controls. b Abnormal ventricle space shown by Texas Red dextran depends on the concentration of Apex1 MO (0.1, 0.15, or 0.2 mM) used for knockdown. Dye was microinjected directly into the ventricle space at 24 hpf. These experiments were performed three times with similar results

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO4-apex1
Knockdown Reagent:	MO4-apex1
Observed In:	brain forebrain ventricular system
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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