FIGURE

Fig. 6

ID

ZDB-FIG-190703-16

Publication

Völkel et al., 2019 - Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development

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Fig. 6

Loss of ezh1 function leads to an increase in ezh2 expression. (A) In situ hybridization showing ezh2 expression in representative embryos at 48 hpf from wild-type (Top) and ezh1^ul3/ul3 crosses. A slight increase in the ezh2 signal at both sides of the midbrain-hindbrain boundary (asterisk) and in the pectoral fin buds (arrowhead) of MZezh1^ul3/ul3 embryos is observed. Scale bar is 500 μm. The numbers indicate the number of embryos with the displayed compared to the total number of embryos analyzed. (B) Expression analysis of ezh1 in wild-type and MZezh1^ul3/ul3 embryos and larvae at 1, 2, 3, 4 and 5 dpf quantified by RT-qPCR show an increase of ezh2 expression in MZezh1^ul3/ul3 mutants. Three independent experiments were performed and statistical analysis was conducted using Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001.

Expression Data

Gene:	ezh2
Fish:	TU ezh1^ul3/ul3 (TU)
Anatomical Terms:	midbrain hindbrain boundary optic tectum pectoral fin bud pharyngeal arch 3-7 retina whole organism
Stage Range:	Long-pec to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ezh1^ul3/ul3 (TU)
Observed In:	midbrain hindbrain boundary pectoral fin bud whole organism
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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