FIGURE

Fig. 2

ID

ZDB-FIG-190625-8

Publication

Pacentine et al., 2019 - Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells

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Fig. 2

Tmie-GFP is present in the hair bundles of MET mutants.

Confocal images of the bundle region in hair cells of the inner ear lateral cristae in 6 dpf larvae. Larvae expressing transgenic Tmie-GFP in the genetic backgrounds of wild type (A), and homozygous mutants for the tip link protein Pcdh15a (B, pcdh15a^psi7), the accessory protein Lhfpl5a (C, lhfpl5a^tm290d), and the Golgi-localized protein Tomt (D, tomt^tk256c). Tomt-deficient fish lack Tmc expression in hair cell bundles [11], presumably mimicking the condition of a triple Tmc knockout. Arrowheads indicate splayed hair bundles. n = 8 each genotype. Scale bar is 5μm.

Expression Data

Gene:	EGFP
Fish:	zf2120Tg (TU) lhfpl5a^{tm290d/tm290d}; zf2120Tg (TU) pcdh15a^psi7/psi7; zf2120Tg (TU) tomt^{tk256c/tk256c}; zf2120Tg (TU)
Anatomical Term:	lateral crista stereocilium bundle
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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