Fig. 9
- ID
- ZDB-FIG-190618-9
- Publication
- Young et al., 2019 - Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification
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Loss of tcf7l1a modifies the gdf6aU768/U768mutant eye phenotype.(A–H) Lateral views of eyes in wildtype (A, E), Ztcf7l1a-/- (B, F), gdf6aU768/U768 (C, G) and double gdf6aU768/U768/Ztcf7l1a-/- (D, H) embryos at 36hpf (A–D) and 52hpf (E–H). Dorsal up, anterior to left. Arrows indicate the lens. Scale bar = 200 µm. (I) Whole mount fluorescent in situ hybridisation for rx3 and pax2a in wildtype (I), Ztcf7l1a-/- (J), gdf6aU768/U768(K) and double gdf6aU768/U768/Ztcf7l1a-/- (L) embryos at 10hpf. Dorsal view, anterior up. Arrows point to rx3eye field expression. Scale bar = 100 µm. (M) Eye volume quantification in wildtype (n = 7), Ztcf7l1a-/- (n = 6), gdf6a-/-(n = 6) and gdf6aU768/U768/Ztcf7l1a-/- double mutant siblings (n = 3) at 36hpf (data in Supplementary file 1R). Single experiment, unpaired t-test. (N) Eye field volume quantification from rx3 fluorescent in situ hybridisation shown in I-L in wildtype (n = 7), Ztcf7l1a-/- (n = 4), gdf6a-/-(n = 8) and gdf6aU768/U768/Ztcf7l1a-/- double mutant siblings (n = 4) at 10hpf (data in Supplementary file 1S). Single experiment, unpaired t-test.
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| Genes: | |
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| Fish: | |
| Anatomical Terms: | |
| Stage: | Bud |
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| Observed In: | |
| Stage Range: | Bud to Long-pec |