FIGURE

Fig. 5-S1

ID

ZDB-FIG-181207-70

Publication

Teng et al., 2018 - Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome

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Fig. 5-S1

Accelerated bone fronts in tcf12; twist1b mutants transgenic for sp7:EGFP.

Live imaging of sp7:EGFP was performed on wild-type sibling controls (n = 11) and tcf12; twist1b mutants (n = 7) at 10 mm standard length. Dorsal views of the skull bones showed accelerated and dysmorphic bone fronts in all mutants examined. To the right, bone fronts of individual fish were traced and overlaid according to genotype. Scale bar, 250 µm.

Expression Data

Antibody:	Ab1-sp7
Fish:	b1212Tg twist1b^el570/el570; tcf12^el548/el548; b1212Tg
Anatomical Terms:	cranial vault osteoblast frontal bone osteoblast parietal bone osteoblast
Stage:	Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	twist1b^el570/el570; tcf12^el548/el548; b1212Tg
Observed In:	frontal bone frontal bone bone growth parietal bone parietal bone bone growth
Stage:	Days 30-44

Phenotype Detail

Acknowledgments

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