FIGURE

Fig. S2

ID

ZDB-FIG-181101-10

Publication

Fernandez et al., 2018 - RES complex is associated with intron definition and required for zebrafish early embryogenesis

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Fig. S2

bud13 knock-down show stronger cell death phenotype.

(A) Lateral view of WT embryos injected with 0.6mM of morpholino antisense oligonucleotide against bud13 mRNA (MObud13) showing different levels of developmental defects (types I to III). Phenotypes are fully rescue with human hBUD13 mRNA. (scale bar: 0.5mm). WT: represent phenotypically wild type sibling from the same mutant fish line. Stronger phenotype is likely due to a depletion of the maternal contribution. (B) bud13 mutant embryos fully rescued by providing 75 pg of hBUD13 mRNA, suggesting that Bud13 function may be conserved across vertebrates (scale bar: 0.5mm). WT: represent phenotypically wild type sibling from the same mutant fish line. (C) 48 hpf, bud13^Δ7/Δ7 embryos showing a similar phenotype to rbmx2^Δ16/Δ16 and snip1^Δ11/Δ11 when partly rescued by injection of 2.5 pg of hBUD13 mRNA (scale bar: 1mm). WT: represent phenotypically wild type sibling from the same mutant fish line.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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