FIGURE

Fig. 5

ID

ZDB-FIG-181003-18

Publication

Yakulov et al., 2018 - CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury

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Fig. 5

Cxcr4b expression in response to injury. a The GFP-RFP-tagged Cxcr4b (cxcr4b:cxcr4b-tFT) was up-regulated in cells adjacent to the laser-induced injury. The arrowhead points to the corpuscle of Stannius. Arrows point to RFP-positive cells, accumulating distally after the injury. Sequential frames were taken from a time-lapse video at t1 = 96 min, t2 = 120 min, and t3 = 160 min after injury (scale bar, 20 µm). b In situ hybridization revealed up-regulated cxcr4b expression in the leading ends of the regenerating tubule 2 h after laser-induced ablation. The cxcr4b up-regulation is outlined in a dashed box. Note that cxcr4b is strongly expressed in the corpuscle of Stannius (arrow) and in the lateral line. c Magnification of the injury region depicted in b. The white arrows point towards the up-regulated cxcr4b, the red arrowhead towards the corpuscle of Stannius

Expression Data

Genes:	cxcr4b EGFP RFP
Fish:	WT uf1Tg; zf512Tg
Condition:	light ablation: pronephros
Anatomical Terms:	corpuscles of Stannius lateral line pronephros pronephros regenerating tissue
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT uf1Tg; zf512Tg
Condition:	light ablation: pronephros
Observed In:	pronephros
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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