FIGURE
Fig. 5
- ID
- ZDB-FIG-180917-28
- Publication
- Svahn et al., 2018 - Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons
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Fig. 5
Blebbing and TDP-43 mislocalisation in a motor neuron over the course of UV-induced degeneration after depletion of microglia. ai Cytoplasmic mTagBFP signal pre-irradiation. aii eGFP-TDP43WT distribution in the soma of the neuron pre-irradiation. aiii Merged images. bi–iv eGFP-TDP43WT signal redistributes into the cytoplasm and shows the blebbing of the cell soma during degeneration. Note the apparent fragmentation of the nucleus, in contrast to the concentration of nuclear eGFP-TDP43WT in the previous figure. Scale = 2 µm |
Expression Data
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Stage Range: | Protruding-mouth to Day 5 |
Expression Detail
Antibody Labeling
Phenotype Data
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Stage Range: | Protruding-mouth to Day 5 |
Phenotype Detail
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Full text @ Acta Neuropathol.