FIGURE

Fig. 4

ID

ZDB-FIG-180828-80

Publication

Wang et al., 2018 - Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B

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Fig. 4

Triptolide suppressed podocyte apoptosis. (A) 84 hpf larvae treated with MTZ for 24 h exhibit remarkable podocyte apoptosis signalling compared to the untreated group (CTL) on immunostains against cleaved caspase-3. The number of apoptotic cells was significantly reduced in the triptolide treatment group. (B) Quantification of caspase-3-stained area (green) to mCherry (red). Data are expressed as the means ± SEM. The confocal images are shown at a maximum intensity projection. (n = 3), **P < 0.01; *P < 0.05. (Original magnification, x1000). (C) Annexin V-FITC/PI staining followed by FCM showed podocytes apoptosis induced by PAN was alleviated by triptolide. **P < 0.01. (On the basis of three triplicate tests).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mi1004Tg; rw0144Tg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: Triptolide
Observed In:	podocyte podocyte apoptotic process regulation of podocyte apoptotic process
Stage:	Day 4

Phenotype Detail

Acknowledgments

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