FIGURE

Fig. 6

ID

ZDB-FIG-180824-7

Publication

Torvund-Jensen et al., 2018 - The 3'UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish

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Fig. 6

The 3’UTRs from mbpa and mbpb affect the cellular localization of mRNA. WISH on transgenic larvae with probes specific for Dendra2 (A,D,G), mbpa (B,E,H), or mbpb mRNA (C,F,I), as indicated. All pictures represent dorsal views of the neck region. mRNAs localized in cell bodies are indicated by black arrows, and localization in myelin sheaths is marked by white arrows. In the Tg(mbpa:Dendra2) larvae, Dendra2 mRNA is exclusively localized in cell bodies (A). This localization is markedly different from the localization of Dendra2 mRNA when the 3’UTR from either mbpa or mbpb is present (D,G). The localization of endogenous mbpa (B,E,H) and mbpb (C,F,I) mRNAs is similar in all three transgenic strains. (J) Enlarged view of the neck region of Dendra2 WISH of (A,D,G).

Expression Data

Genes:	Dendra2 mbpa mbpb
Fish:	zf2108Tg zf2109Tg zf2110Tg
Anatomical Terms:	oligodendrocyte cell body oligodendrocyte myelin sheath
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.