FIGURE

Fig. 5

ID

ZDB-FIG-180823-40

Publication

Ma et al., 2018 - Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model

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Fig. 5

Trafficking analysis of Danio rerio DDX41 (DrDDX41) and identification of the nuclear export signal (NES) motif within it. (A) Schematic diagram of full-length and the NES-mutated DrDDX41. (B) Trafficking of DrDDX41 in response to poly(dA:dT) stimulation at different hours post stimulation (hps) and the contribution of NES motif to the trafficking. Stimulation with poly(dA:dT) induced transportation of DrDDX41 (full-length, a) from nucleus to cytoplasm. Meanwhile, the NES-like-mutant DrDDX41 (NES-M, b) remained in the nucleus without any response to poly(dA:dT) stimulation. Scale bars represent 5 µm. Images were captured under a laser-scanning confocal microscope (Zeiss LSM-710; original magnification, 630×).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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