FIGURE

Fig. S7

ID

ZDB-FIG-180822-36

Publication

Schultz et al., 2018 - Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

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Fig. S7

Ectopic M-phase phosphohistone-H3 positive cells in the telencephalon/forebrain and hindbrain of rb1D7/D7 mutant 5 dpf larva. A wildtype +/+ and B rb1D7/D7 mutant 5 dpf gross morphology. C-J Cryosections were labeled with antibodies to the neuronal marker HuC/D (red) and mitotic M-phase marker phosphohistone-H3 (green). Sections through the telencephalon (C-F) and hindbrain (G-J) show that in wild type mitotic cells are absent or rare, but in the rb1D7/D7 mutant many ectopic phosphohistone-H3 positive cells are scattered throughout the region containing HuC/D-positive cell bodies of neurons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.