FIGURE

Fig. 9

ID

ZDB-FIG-180709-44

Publication

Andrzejczuk et al., 2018 - Tal1, Gata2a, and Gata3 Have Distinct Functions in the Development of V2b and Cerebrospinal Fluid-Contacting KA Spinal Neurons

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Fig. 9

Expression of Tg(-8.1gata1:gata1-EGFP) in single and double mutants. Lateral views of 30 h Tg(-8.1gata1:gata1-EGFP) WT sibling (A) and single and double mutants as indicated (B–F). Dorsal, top; anterior, left. Dashed rectangle regions in main panels (A–F) are shown in magnified view in adjacent (A′–F′) panels. Dashed lines indicate ventral limit of spinal cord. White arrows indicate KA″ axons, magenta arrows indicate KA′ axons and white arrowheads mark V2b axons. KA″ and KA′ axons are ipsilateral and ascending whereas V2b axons are ipsilateral descending. KA″ neurons appear to form normally and extend WT-like axonal projections in tal1;gata3 double mutants (E,E′). In contrast, even though GFP-expressing V2b cells are present in both gata3 (C,C′) and gata2a (D,D′) single mutants there are no GFP-expressing V2b cells in gata2a;gata3 double mutants (F,F′). Scale bar = 50 microns.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf100Tg gata2a^um27/um27; zf100Tg gata3^{sa0234/sa0234}; zf100Tg tal1^{t21384/t21384}; zf100Tg gata2a^um27/um27; gata3^{sa0234/sa0234}; zf100Tg tal1^{t21384/t21384}; gata3^{sa0234/sa0234}; zf100Tg
Observed In:	interneuron Kolmer-Agduhr neuron medial region Kolmer-Agduhr neuron ventral-most region Kolmer-Agduhr neuron ventro-medial region spinal cord VeLD
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.